852TO STUDY OUTCOME OF INTRAOPERATIVE DEXMEDETOMIDINE ON POSTOPERATIVE COGNITIVE DYSFUNCTION OF AGED INDIAN PATIENTSPostoperative cognitive dysfunction is one of the most common complications affecting the central nervous system after general anaesthesia and surgery especially in elderly patients. It’s characterized by short-term cognitive decline and includes memory, mood, confusion, and sleep disorders. Its medical manifestations include cognitive disorder, personality exchange and memory loss, intellectual problems and social impairment. Starting with demographic data, the mean age of the included cases was 69.98 and 70.02 years in the Dex and control groups, respectively. Males represented the majority of the included cases, as they formed 100 and 98.9% of cases in the same groups, respectively. Body mass index (BMI) had mean values of 28.11 and 27.43kg/m2 in the two groups, respectively. Dexmedetomidine admin is related with a considerable development of cognitive function after surgery in the elderly inhabitants. It is linked with a better analgesic and sedative profile and decreased neurological inflammatory markers (S100B). Conversely, we should closely monitored for side effects like bradycardia and hypotension in patientsSrikanth@gmail.comResearch942018Post-operative cognitive dysfunction,Dexmedetomidine, Sedation, SevofluraneGowtham Kumar Reddy K,Srikanth SAssistant Professor of Anaesthesiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, (Affiliated to Bharath University, Chennai), India,Assistant Professor of Anaesthesiology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry, (Affiliated to Bharath University, Chennai), India