874FORMULATION AND IN-VITRO EVALUATION OF TACRINE ORAL THIN FILMSIn present study oral thin films of Tacrine were developed to have a faster on set of action. The oral thin films were developed by using polymers HPMC E5, HPMC E 15 and PVP K90.Oral thin films were prepared by employing solvent casting method. Propylene glycol was selected as permeation enhancer and plasticizer. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F6, and all the formulations were evaluated for various physical parameters Physical appearance, Weight variation, Thickness, Folding endurance, Tensile strength, Drug content, Moisture uptake, Moisture content and all the results were found to be were found to be with in the pharmacopoeial limits, invitro drug release studies by using dialysis membrane. Among all the 6 formulations F1 formulation which contain PVP K90 100mg and shown 97.07. % cumulative drug release within 30 min. And compared to HPMC E15, HPMC E5 and PVP K90, PVP K90 showed better drug release profile.ragavasammulu@gmail.comResearch1512024Tacrine, HPMC E15, HPMC E5, PVP K90 and HPMC E 15Allam Rajendar,Dr. Purushothaman MStudent, Department of Pharmaceutics, KLR Pharmacy College, Palwancha, Telangana 507115, India,Principal, Department of Pharmaceutics, KLR Pharmacy College, Palwancha, Telangana 507115, India