878TO STUDY THE ASSOCIATION OF BIOMARKERS ESR AND HS CRP AND ITS OSSIFICATION OF POSTERIOR LONGITUDINAL LIGAMENTOssification of the spinal ligaments is the time period used to describe heterotopic ossified lesions that may arise during the spine. Ossification of the posterior longitudinal ligament (OPLL) has by means of ectopic new bone formation which serves because the replacement for ligamentous tissue. The present study aims to find out Clinical exploration of ossification of posterior longitudinal ligament associated with serum biomarker of ESR and hs CRP. A prospective study conducted at a tertiary care centre of Sri Lakshmi Narayana Institute of Medical sciences, Pondicherry, and Sree Balaji Medical College and Hospital, Chrompet, Chennai and approved by the regional ethical committee all patients with OPLL and controls were recruited from Orthopaedics Department. The diagnosis of OPLL was based on radiological findings, together with radiographs and computed tomography (CT) scans of the cervical, thoracic, lumbar spine are included in this study. A total of 95 patients with OPLL (56 men and 39 women: average age 75.3 ± 17.4 years, range 40±85 years) were available for a follow-up of more than 2 years with radiological examinations. The average follow-up duration was 5.2 ± 2.1 years (range, 2±10 years). The outcomes discovered inside the observe recommended that hs-CRP within the patients with OPLL turned into higher as compared to the controls. hs-CRP within the OPLL progression institution changed into higher than in the non-progression group, indicating that infection might arise in OPLL. We accept as true with that those findings represent new understanding that will aid the knowledge of the neighborhood pathology of OPLAssistant Professor of Anaesthesiology, Sree Balaji Medical College and Hospital, Chrompet, Chennai (Affiliated to Bharath University, Chennai), IndiaResearch842017Ossification of posterior longitudinal ligament, ESR, hs-CRP and myelopathyKedarasetty Vijaya Kumar,Srikanth Reddy DumpaAssistant Professor of Anaesthesiology, Sree Balaji Medical College and Hospital, Chrompet, Chennai (Affiliated to Bharath University, Chennai), India,Assistant Professor of Anaesthesiology, Sree Balaji Medical College and Hospital, Chrompet, Chennai (Affiliated to Bharath University, Chennai), India