934PHARMACOLOGICAL AND COMMUNITY-BASED APPROACHES IN MIGRAINE MANAGEMENT: CLINICAL INSIGHTS AND PHARMACIST CONTRIBUTIONSMigraine is a well-known and debilitating neurological disease when a patient experiences regular times of moderate to severe headache, which are usually accompanied by nausea, vomiting, photophobia, and phonophobia. It has a considerable percentage of the world population and plays an important role in lowering the quality of life, work productivity, and high healthcare expenditures. Migraine pathophysiology encompasses complicated neurovascular processes, such as trigeminovascular system stimulation, neuropeptide discharge, such as calcitonin gene-related peptide (CGRP), cortical spreading depression, and central pain pathway sensitization. Patients with regular or frequent migraine attacks or severe attacks should preventive treatments and include beta-blockers, antiepileptic drugs, antidepressants and monoclonal antibodies against CGRP or its receptor. Community-based healthcare interventions are also important in enhancing the outcome of migraines alongside pharmacological management. Community pharmacists have a unique role to play in terms of identifying the signs of migraine at early stages, determining how the headache occurs, and identifying the red flag symptoms that need medical attention. They are also instrumental in educating proper use of non-prescription drugs, medication overuse headache, adherence to preventive treatment, as well as teaching the patient’s lifestyle best practices, including stress reduction, sleep hygiene, hydration, and dietary aggravants. The working process of pharmacists with physicians and other medical practitioners improves the quality of migraine management and timely referral in case of necessity. Individualized treatment plans and a better perception of disease management among the patients are further enhanced by pharmacist-led counseling services and medication review services. On the whole, combination of pharmacological innovations and community-based pharmaceutical therapy represents a holistic approach of enhancing clinical performance and minimizing the socioeconomic burden of migraine badamdurga2006@gmal.comResearch1712026Migraine management; Pharmacotherapy; Community pharmacy; Pharmacist interventionsBadam Durga1*, Paluvadi Bhavana1, Madhamanchi Pujitha1, Shaik Apsana,Dr. Purushothaman MPharm.D, IV Year Student, Department of Pharmacy Practice, KLR Pharmacy College, Paloncha, Telangana, India,Professor, Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Telangana, India.